Description
Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline
ethanolamine to phosphocholine
phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine
phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline
ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus